Principle Investigator	Yuji Kohara Project Professor at Genome Biology Laboratory, National Institute of Genetics
Keyword for Support Function	Advanced Genome Analysis
Grant period	FY 2016 – 2021
URL	http://www.genome-sci.jp/

Support Categories

Support activity for the networking base of a large-scale genome sequencing analysis

Support for novel genome sequencing	We determine the genomes of plant, vertebrate (except humans), invertebrate, algae, protozoans, bacteria, etc. using the most advanced next-generation sequencer: a sequencer which can read long-chain baseline DNA. This enable us to conduct high-quality genome sequencing.
Support for mutation analysis	We conduct somatic mutation analysis, Haplotype analysis, and analysis on SNP (single Nucleotide Polymorphism) and CNV (Copy Number Variation) on the organisms having their genome sequencing completed with the cutting-edge system and technology.
Support for Modification Analysis	We support analysis on the modifications of epigenome, RNA, chromosome structure, and binding protein, etc. We also conduct analysis on DNA modification and RNA modification using a technique to measure single molecule.
Support for RNA analysis	We use the RNA samples of organisms having their genome sequencing completed to analyze the number of copied RNA species, stability, GuideRNAs, splicing, and IncRNA and others.
Support for metagenome, environmental genome, and hologenome analysis	We support single cell genome analysis, metagenome analysis, and hologenome analysis on the various samples. This analysis includes DNA, RNA, and single cell analysis in symbiosis and mutual interaction on from the biological samples to the environmental samples.
Support for High Sensitivity Genomic DNA Analysis	With the advanced genome sequencing system which enables us to sequence a single molecule or a single cell, we support to sequence ultra-low volume samples. We support to analyze the change over time. In addition, we organize the training course for technical supporters.

Support activity for networking of advanced information analysis

Support for developing a high-throughput fundamental analysis pipeline	We provide the analysis pipeline by developing a high-throughput workflow that can deal with the bigdata. We support to analyze the data using the advanced analysis pipeline.
Support for developing a comprehensive genome annotation	We develop a technique to obtain high-quality genome annotation or metagenomic annotation.
Support for developing the advanced information analysis on multiple integrated genome information	We develop technologies to conduct integrative analysis on the various and a large amount of multiple genomic information obtained by genome analysis and RNA analysis.
Construction of knowledge base supported by Artificial Intelligence	We aim to automate the advanced analysis support with the accumulated data and the knowledge obtained in the platform.
Support for Development and Proposal for the high advanced information processing technology	We develop the advanced processing technology to support scientific challenges that require very high analysis technology in the field of genosme science. We also utilize it to our support program.